Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 18.18
Human Site: Y595 Identified Species: 36.36
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 Y595 S E T F V G D Y T L S F W R N
Chimpanzee Pan troglodytes XP_514650 1630 185027 Y935 S E T F V G D Y T L S F W R N
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 Y595 S E T F V G D Y T L S F W R N
Dog Lupus familis XP_542998 1249 143812 K564 L S F W R N G K V Q H C R I H
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 Y595 S E T F V G D Y T L S F W R N
Rat Rattus norvegicus P10686 1290 148530 Y595 S E T F V G D Y T L S F W R N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514 I11 N R W F L N I I Q D G F M N G
Frog Xenopus laevis Q32NH8 758 87399 K132 T V T N M D R K D L M D Q W I
Zebra Danio Brachydanio rerio A5D6R3 784 89362 E158 V S N M S Q K E K L D H W I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 K469 R K I L I K N K R M K P E V E
Honey Bee Apis mellifera XP_624101 1134 132613 V508 L S D G T F L V R Q C V T F V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 F314 S H E N K E W F H S Q L S R H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 13.3 13.3 13.3 N.A. 0 0 N.A. 13.3
P-Site Similarity: 100 100 100 13.3 N.A. 100 100 N.A. N.A. 26.6 26.6 13.3 N.A. 26.6 0 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % C
% Asp: 0 0 9 0 0 9 42 0 9 9 9 9 0 0 0 % D
% Glu: 0 42 9 0 0 9 0 9 0 0 0 0 9 0 9 % E
% Phe: 0 0 9 50 0 9 0 9 0 0 0 50 0 9 0 % F
% Gly: 0 0 0 9 0 42 9 0 0 0 9 0 0 0 9 % G
% His: 0 9 0 0 0 0 0 0 9 0 9 9 0 0 17 % H
% Ile: 0 0 9 0 9 0 9 9 0 0 0 0 0 17 9 % I
% Lys: 0 9 0 0 9 9 9 25 9 0 9 0 0 0 0 % K
% Leu: 17 0 0 9 9 0 9 0 0 59 0 9 0 0 0 % L
% Met: 0 0 0 9 9 0 0 0 0 9 9 0 9 0 0 % M
% Asn: 9 0 9 17 0 17 9 0 0 0 0 0 0 9 42 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % P
% Gln: 0 0 0 0 0 9 0 0 9 17 9 0 9 0 0 % Q
% Arg: 9 9 0 0 9 0 9 0 17 0 0 0 9 50 9 % R
% Ser: 50 25 0 0 9 0 0 0 0 9 42 0 9 0 0 % S
% Thr: 9 0 50 0 9 0 0 0 42 0 0 0 9 0 0 % T
% Val: 9 9 0 0 42 0 0 9 9 0 0 9 0 9 9 % V
% Trp: 0 0 9 9 0 0 9 0 0 0 0 0 50 9 0 % W
% Tyr: 0 0 0 0 0 0 0 42 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _